艾滋病患者抗逆转录病毒治疗依从性现状及其影响因素分析

The status quo and influencing factors of antiretroviral therapy compliance in AIDS patients

目的 探讨艾滋病患者抗逆转录病毒治疗依从性现状及其影响因素。方法 回顾性分析我中心随访管理并转介至定点医院治疗的艾滋病患者150例,临床资料显示所有患者均接受连续1年抗逆转录病毒治疗,根据用药依从性情况分为依从性良好组与依从性较差组,分析影响其治疗依从性的相关因素。结果 150例患者中治疗依从性较差30例,依从性较好120例;单因素分析显示,文化程度低、治疗期间出现不良反应、对疾病与治疗知识缺乏了解、对待疾病态度消极与患者治疗依从性较差相关。结论 艾滋病患者抗逆转录病毒治疗依从性有待提高,文化程度低、治疗期间出现不良反应、对疾病与治疗知识缺乏了解、对待疾病态度消极是其独立影响因素,临床需针对上述因素制定干预措施,以提高患者治疗依从性。

Objective To investigate the status and influencing factors of antiretroviral therapy compliance in AIDS patients.Methods The clinical data of 150 AIDS patients who were followed up and managed by our center and were referred to designated hospitals for treatment were retrospectively analyzed.All of them received antiretroviral therapy for one year.In the good compliance group and the poor compliance group,the related factors affecting their treatment compliance were analyzed.Results Among the150 patients,30 had poor treatment compliance,and 120 had good compliance;univariate analysis showed that low educational level,adverse reactions during treatment,lack of understanding of disease and treatment knowledge,negative attitude towards disease and patients.Poor treatment compliance was associated with a statistically significant difference(P<0.05).Logistic regression analysis showed that low educational level,adverse reactions during treatment,lack of understanding of disease and treatment knowledge,and negative attitude towards disease were independent risk factors for patients’ treatment compliance(P<0.05 and OR≥1).Conclusion The compliance of AIDS patients with antiretroviral therapy needs to be improved.Low education level,adverse reactions during treatment,lack of understanding of disease and treatment knowledge,and negative attitude towards disease are independent influencing factors.Clinical interventions should be formulated for the above factors.To improve patient compliance with treatment.