不同年龄段急性脑梗死患者rt-PA静脉溶栓治疗疗效分析

Effect of RT PA Intravenous Thrombolytic Therapy on Acute Cerebral Infarction In Different Age Groups

目的 对比不同年龄段急性脑梗死患者重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗疗效。方法 回顾性分析我院50例接受rt-PA静脉溶栓治疗的76~91岁的急性脑梗死患者临床资料,纳入A组;将同期50例接受rt-PA静脉溶栓治疗的60~75岁急性脑梗死患者临床资料,纳入B组;比较两组治疗7d结束时的疗效;比较两组治疗前、治疗7d结束时实验室指标[D-二聚体(D-dimer,D-D)、纤维蛋白原(Fibrinogen,Fib)];比较两组治疗期间不良反应发生情况。结果 治疗7d结束时,B组有效率高于A组,差异有统计学意义(P<0.05);治疗7d后,两组D-D、Fib均低于治疗前,且B组低于A组,差异有统计学意义(P<0.05);治疗期间,两组不良反应发生率比较,差异无统计学意义(P>0.05);结论 rt-PA静脉溶栓治疗在不同年龄段治疗的疗效较好,可有效降低D-D、Fib水平,不增加不良反应,安全性较好,且年龄越小治疗疗效果越好。

Objective To compare the efficacy of recombinant tissue plasminogen activator(RT PA)intravenous thrombolysis in patients with acute cerebral infarction at different ages.Methods The clinical data of 50 patients with acute cerebral infarction aged76~91 who received RT PA intravenous thrombolytic therapy were retrospectively analyzed;The clinical data of 50 patients with acute cerebral infarction aged 60~75 who received RT PA intravenous thrombolytic therapy in the same period were included in group B;The curative effects of the two groups at the end of 7 days were compared;The laboratory indexes [D-Dimer(D-D),fibrinogen(FIB)]of the two groups before treatment and at the end of 7 days were compared;Adverse reactions were compared between the two groups.Results At the end of 7 days,the effective rate of group B was higher than that of group A(P<0.05);After 7 days of treatment,D-D and FIB of two groups were lower than before treatment,and group B was lower than group A,the difference was statistically significant(P<0.05);During the treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05);Conclusion rt-PA intravenous thrombolytic therapy in different age groups has good curative effect,can effectively reduce the D-D,FIB levels,does not increase adverse reactions,has good safety,and the younger the age,the better the therapeutic effect.