鲍曼不动杆菌在烧伤患者中的流行性及其耐药机制的研究进展

Research progress on the prevalence of[WTHX]Acinetobacter baumannii in burn patients and its drug resistance mechanism

近年来随着抗生素在临床上的大量应用,烧伤感染患者中鲍曼不动杆菌(Ab)感染率呈逐渐上升的趋势,且多重耐药情况日趋严重,对Ab耐药机制的研究成为当前的热门课题。但因其机制错综复杂,到目前为止尚未达成共识。本文从Ab的毒力因子、在烧伤患者中的流行性、对临床常用药物的耐药情况及最近国内外学者对常见抗生素包括β-内酰胺类、氨基糖苷类、四环素类等的耐药机制研究成果作一综述。

In recent years,with the extensive application of antibiotics in clinic,the infection rate of Acinetobacter baumannii(Ab)in patients with burn infection is gradually increasing,and the situation of multiple drug resistance is becoming more and more serious.The research on the mechanism of drug resistance of Ab has become a hot topic.However,because of its complex mechanism,no consensus has been reached so far.This article reviews the virulence factors of Ab,its prevalence in burn patients,drug resistance to commonly used clinical drugs,and recent domestic and foreign scholars on the resistance mechanisms of common antibiotics includingβ-lactam,aminoglycosides,tetracyclines,etc.