表皮和表皮干细胞衰老的研究进展

Research progress on the senescence of epidermis and epidermal stem cells

表皮位于机体的最外层,是保护机体免受外界有害物质损伤的首道屏障。表皮干细胞位于表皮基底层,是表皮结构维持的种子细胞,其分裂增殖、分化能力和凋亡水平同表皮稳态维持和损伤修复密切相关。本文介绍了表皮的结构、功能、细胞组成和损伤修复能力随衰老发生的变化,并总结了表皮干细胞分裂增殖、分化和凋亡随衰老发生的变化。分析表明,表皮内细胞成分和细胞功能状态的变化同表皮衰老密切相关,有望成为抑制皮肤衰老的靶点。

Located in the outermost layer of the body,epidermis is the first barrier to protect the body from external harmful substances.Mainly distributed in the basal layer of the epidermis,epidermal stem cells are seed cells whose proliferation,differentiation and apoptosis are closely related to the maintenance of epidermal homeostasis and damage repair.The senescence-related changes of epidermal structure,function,cell composition and damage repair ability have been introduced by reviewing the researches.Also the senescence-related changes of division,proliferation,differentiation and apoptosis of epidermal stem cells have been summarized.The analysis shows that the changes of cell composition and cell functional status in the epidermis are closely related to the senescence of epidermis,and these are expected to become a treatment target for reversing skin aging.