咖啡因预防白内障发生的研究进展

Advances in the Prevention of Cataract by Caffeine

咖啡因又称1,3,7-三甲基黄嘌呤,是一种生物碱,其在神经病学、内科学、妇产科学以及儿科学等领域被广泛研究。近年来,眼科领域对咖啡因也有了一些新的认识。白内障作为人类第一大致盲眼病,目前手术是其唯一根治的方法,部分研究发现咖啡因可以通过抗氧化及抑制细胞凋亡等作用来预防白内障的发生。鉴于此,咖啡因与白内障的关系值得进一步深入研究。笔者就咖啡因在预防白内障发生中的作用机制进行探讨,以期为防治白内障提供新的理论依据。

Caffeine,the common term for 1,3,7-trimethylxanthine,is an alkaloid.It is widely studied in the fields of neurology,internal medicine,pediatrics,obstetrics and gynecology.In recent years,there has also been some new understanding of caffeine in the field of ophthalmology.Cataract is the leading cause of blindness in humans,so the prevention and treatment of cataract is extremely significant.Currently,surgery is the only treatmen.Some research has revealed that caffeine can prevent cataract by anti-oxidation and inhibition of apoptosis.Therefore,the relationship between caffeine and cataract is worth discussing.This review puts emphasis on the research progress of the mechanism of caffeine in the prevention of cataract in an effort to provide insights for the therapeutic approach to cataract.