B细胞在骨破坏性疾病中作用的研究进展

Progress of research on the role of B lymphocytes in bone destructive diseases

骨骼系统与免疫系统密切相关,B细胞作为免疫系统的重要组成部分,通过RANKL/RANK/OPG轴、分泌细胞因子和抗体等方式直接或间接地调控骨稳态,在骨破坏性疾病的发生发展中发挥关键作用。本文就B细胞和骨组织的关系及B细胞在骨破坏性疾病中的作用作一综述,为骨破坏性疾病的研究和治疗提供新思路。

There is a close relationship between the skeletal system and the immune system. As an important part of the immune system, B lymphocytes regulate bone homeostasis through the RANKL/RANK/OPG axis and the production of cytokines and antibodies, which play a key role in the occurrence and development of bone destructive diseases. This review will discuss the interaction between B lymphocytes and bone homeostasis and the role of B lymphocytes in bone destructive diseases, hoping to provide new ideas for research and treatment of bone destructive diseases.