1,2,2-三芳基乙酮化合物合成方法研究进展

Recent advances in the synthesis of 1,2,2-triarylacetophenones

1,2,2-三芳基乙酮化合物是合成众多天然产物和上市药物的重要中间体,也被广泛应用于生物、农药、高分子以及材料科学等众多领域,具有广阔的发展前景.因此,发展简便、高效的方法实现该类化合物的不对称合成具有重要的理论和现实意义.近20年来,芳基乙酮类化合物合成工作取得了重要进展.本文根据合成策略的不同对反应进行分类,并综述了1,2,2-三芳基乙酮化合物合成方法研究进展,详细讨论了反应底物普适性、机理和应用,并对该领域的发展前景和局限性进行了总结.

1,2,2-Triarylacetophenone compounds are important intermediates for the synthesis of many natural products and marketed drugs,and they are also widely used in many fields such as biology,pesticides,polymers and materials science,which have great prospects.Therefore,it is of great theoretical and practical significance to develop simple and efficient methods for the asymmetric synthesis of these compounds.In the past two decades,important progress has been made in the synthesis of aryl acetophenones.In this review,the reactions are classified according to different synthesis strategies,and the progress of synthesis methods of 1,2,2-triarylacetophenone compounds is summarized.The reaction substrate compatibility,mechanism,applications,development prospects and limitations in this field are also discussed in detail.