酪酸梭菌活菌胶囊联合三联疗法治疗幽门螺杆菌相关性慢性胃炎的临床效果

Clinical effect of clostridium butyricum capsule combined with triple therapy in the treatment of Helicobacter pylori associated chronic gastritis

目的观察幽门螺杆菌(Hp)相关性慢性胃炎采用酪酸梭菌活菌胶囊联合三联疗法治疗的临床效果。方法选取2020年4月—2021年4月泉州市泉港医院收治的Hp相关性慢性胃炎患者110例,根据随机数字表法分为观察组和对照组,每组55例。对照组采取克拉霉素+奥美拉唑+阿莫西林(三联疗法)治疗,观察组则采取酪酸梭菌活菌胶囊联合三联疗法治疗,2组治疗周期为28 d。比较2组患者治疗总有效率,治疗前后症状积分、炎性因子水平,Hp根除率及不良反应。结果观察组患者治疗总有效率为96.36%,高于对照组的81.82%(χ^(2)=5.986,P=0.014);治疗28 d后,2组嗳气、腹痛、胀气、泛酸积分均较治疗前下降,2组C反应蛋白(CRP)、白介素⁃6(IL⁃6)、白介素⁃8(IL⁃8)、肿瘤坏死因子⁃α(TNF⁃α)水平均较治疗前降低,且观察组上述指标低于对照组(P均<0.01);观察组患者Hp根除率为94.55%,高于对照组的58.18%(χ^(2)=20.147,P<0.001);观察组不良反应总发生率为7.27%,低于对照组的21.82%(χ^(2)=4.681,P=0.031)。结论酪酸梭菌活菌胶囊联合三联疗法治疗Hp相关性慢性胃炎的总有效率高,可明显缓解临床症状,降低炎性反应,提高Hp根除率,且不良反应发生率低,值得推广应用。

Objective To observe the effects of clostridium butyricum capsule combined with triple therapy for Heli⁃cobacter pylori(Hp)associated chronic gastritis.Methods A total of 110 patients with Hp⁃related chronic gastritis admitted to Quangang District Hospital in Quanzhou City from April 2020 to April 2021 were selected and divided into observation group and control group according to the random number table method,with 55 cases in each group.The control group was treated with triple therapy,while the observation group was treated with clostridium butyricum capsule combined with triple therapy.Both groups were treated for 28 days.The total effective rate of treatment,symptom scores,inflammatory factor levels,Hp eradication rate and adverse reactions before and after treatment were compared between the two groups.Results The total effective rate of patients in the observation group was 96.36%,which was higher than 81.82%in the control group(χ^(2)=5.986,P=0.014);After 28 days of treatment,the belching,abdominal pain,flatulence,and pantothenic acid scores in the two groups were all decreased compared with those before treatment,the levels of C⁃reactive protein(CRP),interleukin⁃6(IL⁃6),interleukin⁃8(IL⁃8)and tumor necrosis factor⁃α(TNF⁃α)in both groups were lower than those before treatment,and the observation group was lower than the control group(all P<0.01);The Hp eradication rate in the observation group was 94.55%,which was higher than 58.18%in the control group(χ^(2)=20.147,P<0.001);The total incidence of adverse reactions in the observation group was 7.27%,which was lower than 21.82%in the control group(χ^(2)=4.681,P=0.031).Conclusion The clostridium butyricum capsule combined with triple therapy can increase the clinical effect of Helicobacter pylori associated chronic gastritis,relieve clinical symptoms,regulate inflammatory factors,improve Hp eradication rate and reduce adverse reactions,thus it is worth local promoting.