摘要
前列腺导管内癌(IDC-P)是前列腺癌的一种特殊病理亚型.伴随着前列腺肿瘤的进展, IDC-P的发生率亦逐渐增高,尤其在晚期前列腺癌患者中具有较高比例.近年来越来越多的研究表明, IDC-P的检出与各阶段前列腺癌患者的不良预后均密切相关.因此,尽管学界在IDC-P诊断、肿瘤起源等问题上还存在争论, IDC-P仍受到临床和病理医生越来越多的关注.本文将从IDC-P的组织病理学特征、肿瘤起源、病理争议、临床预后、治疗现状以及分子特征方面对其进行综述.
Intraductal carcinoma of the prostate(IDC-P) is a specific pathological subtype of prostate cancer. With the progression of prostate cancer, the incidence of IDC-P also gradually increases, especially at the advanced tumor stage. In recent years, an increasing number of studies have demonstrated that the existence of IDC-P is closely related to the poor prognosis of prostate cancer patients at all stages. Therefore, although the pathological description and tumor origin of IDC-P remain debatable, IDC-P continues to receive increasing attention from clinicians and pathologists. This article has systematically summarized the histopathological characteristics,tumor origin, pathological debate, clinical prognosis, treatment status, and molecular characteristics of IDC-P.
作者
赵劲歌
孙光曦
朱莎
戴津东
许南炜
王志鹏
沈朋飞
刘振华
杨璐
聂玲
陈雪芹
张孟尼
陈铌
曾浩
李响
周桥
魏强
ZHAO JingGe;SUN GuangXi;ZHU Sha;DAI JinDong;XU NanWei;WANG ZhiPeng;SHEN PengFei;LIU ZhenHua;YANG Lu;NIE Ling;CHEN XueQin’;ZHANG MengNi;CHEN Ni;ZENG Hao;LI Xiang;ZHOU Qiao;WEI Qiang(Department of Urology,West China Hospital of Sichuan University,Chengdu 610041,China;Department of Pathology,West China Hospital of Sichuan University,Chengdu 610041,China)
出处
《中国科学:生命科学》
CSCD
北大核心
2022年第11期1626-1635,共10页
Scientia Sinica(Vitae)
基金
国家自然科学基金(批准号:82172785、81974398、82203110)资助。