抑郁症病因学和治疗学的研究进展

Advances in the etiology and clinical treatment of depression

抑郁症是一种常见的精神疾病,因其高患病率、高致残率和高自杀率给个体、家庭和社会带来了严重损害,一直是业界学者关注的重点.大量的人力和物力投入到了抑郁症病因学和治疗学的研究中,力图更好地认识其产生的原因和病理机制,从而更好地打开改善治疗结局与康复的迷局.近年来,抑郁症在流行病学、分子遗传学、神经影像学、神经免疫学、肠道微生物和治疗等领域的研究取得了重要进展.本文将从上述领域进行回顾,同时也将介绍四川大学华西医院心理卫生中心所做的相关工作,以期为精神科医师和抑郁症领域研究者提供参考.

Depression is a common mental illness with high disability and suicide rates.Its etiology and mechanism are still unclear,and its clinical treatment has raised concerns among researchers.To better understand the etiology and improve the treatment outcomes of depression,we have invested in various resources.Recently,significant progress has been achieved in the fields of genetics,neuroimaging,gut microbiota,and neuroimmunity in depression.Moreover,many important findings have been identified in the antidepressant treatment,physical therapy,and psychological treatment of depression.This review mainly focuses on the progress of the etiology and clinical treatment of depression to provide evidence for psychiatrists.