阿尔茨海默病血浆和肠道菌群中生物标志物的研究进展

Recent advances in blood and gut microbiota biomarkers for Alzheimer’s disease

阿尔茨海默病(Alzheimer’s disease, AD)是一种常见的神经退行性疾病,在老年人中患病率高.但目前其发生机制尚不明确,而且缺乏便捷的早期诊断手段,因而难以在疾病早期进行干预和治疗.近几年,随着质谱、免疫学方法等新技术的发展,外周血Aβ、P-tau、外泌体、miRNA、肠道细菌等成为AD早期诊断及病情监测的潜在生物学标志物.本文就目前AD外周血生物标志物及AD相关肠道菌群生物标志物现况进行了综述,旨在为AD的早期诊断和预测疾病进展提供参考.

Alzheimer’s disease(AD) is one of the most common neurodegenerative diseases, with a high prevalence among the elderly.However, the mechanism of its occurrence is not clear, and there is a lack of convenient means of early diagnosis, which makes it difficult to intervene in and treat the disease in its early stage. In recent years, with the development of mass spectrometry,immunological methods and other new technologies, potential biomarkers for early diagnosis and disease monitoring of Alzheimer’s disease have been identified, including peripheral blood Aβ, p-tau, exosomes, mi RNA, and intestinal bacteria. In this article, we reviewed the current research status of AD peripheral blood biomarkers and AD-related intestinal microbiota biomarkers, in order to provide a reference for the early diagnosis and prediction of the disease progression.