G蛋白调节剂的研究进展

Research progress on the G protein modulators

异源三聚体G蛋白是一类能与鸟嘌呤核苷酸结合,具有GTP水解酶活性的信号转导蛋白。G蛋白由α、β、γ三个亚基组成,是GPCR信号通路中“分子开关”。异常活化的G蛋白与葡萄膜黑色素瘤、哮喘等疾病直接相关,直接靶向G蛋白是上述疾病有前景的治疗策略。本文将简述G蛋白的分类及生理功能,并综述G蛋白与疾病的关系以及G蛋白调节剂的研究进展。

Heterotrimeric G proteins are classes of signal-transducing proteins that bind to guanine nucleotides and possess GTP hydrolase activity.G proteins are composed of three subunits α,β,andγ,and are considered as the"molecular switch"in the GPCR signaling pathway.The abnormal activation of G protein is strongly related to diseases such as uveal melanoma,asthma,et al.,making directly targeting G protein as an promising strategy for combating diseases.In this review,the classification and physiological functions of G protein are briefly described,and the research progress of G proteins in diseases,G protein modulators are reviewed.