山蜡梅叶中1个新的愈创木烷型倍半萜

A new guaiane-sesquiterpenoid from the leaves of Chimonanthus nitens Oliv.

运用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱及半制备高效液相等多种色谱分离技术,从山蜡梅叶中分离得到9个化合物,通过质谱、核磁共振波谱以及单晶衍射数据,分别鉴定为:chimnitensene B(1)、1α-hydroxyisodauc-4-en-15-al(2)、trans-4,5-dihydroxycorocalane(3)、trefoliol B(4)、oplopanone(5)、oplodiol(6)、3-(3’-hydroxybutyl)-2,4,4-trimethylcyclohexa-2,5-dienone(7)、9(S)-4-oxo-7,8-dihydro-β-ionol(8)和saniculamoid D(9)。其中,化合物1为新的愈创木烷型倍半萜,化合物2~9为首次从山蜡梅植物中分离得到。

Nine compounds were isolated from the leaves of Chimonanthus nitens Oliv.by silica gel,ODS,Sephadex LH-20 column chromatography and semi-preparative HPLC.They were identified as chimnitensene B(1),1α-hydroxyisodauc-4-en-15-al(2),trans-4,5-dihydroxycorocalane(3),trefoliol B(4),oplopanone(5),oplodiol(6),3-(3’-hydroxybutyl)-2,4,4-trimethylcyclohexa-2,5-dienone(7),9(S)-4-oxo-7,8-dihydro-β-ionol(8),and saniculamoid D(9)respectively,by MS,NMR and single crystal diffraction.Among them,compound 1 is a new guaianesesquiterpenoid,and compounds 2-9 were isolated from this plant for the first time.