多功能蛋白p62在肾脏疾病中的研究进展

Progress of multifunctional protein p62 in kidney disease

p62是机体内普遍存在的一种含有6个结构域的多功能蛋白。p62参与选择性自噬降解泛素化底物,并已成为监测细胞自噬的重要生物标志物。除此之外,p62还参与氧化应激、细胞营养感知、细胞凋亡和代谢重编程等众多生物学过程。p62的表达受TFEB等转录因子的调控。既往研究发现p62基因突变与神经系统等疾病密切相关,近来还发现p62参与维护肾小球足细胞、系膜细胞和肾小管上皮细胞的正常功能。基于p62蛋白功能的多样性与重要性,该蛋白有望成为治疗肾脏疾病的靶点之一。

p62 is a ubiquitous multifunctional protein with six domains in the body.p62 is mainly involved in selective autophagic degradation of ubiquitinated substrates.Hence,it has become an important biomarker of monitoring autophagic flux.p62 is also involved in oxidative stress.Additionally,p62 participates in series of cellular biological processes including nutrient sensing,apoptosis and metabolic reprogramming.The expression of p62 is regulated by some transcriptive factors such as TFEB.The mutations of p62 gene are associated with neurological and other disorders.It has been shown that p62 is necessary for maintaining normal function of glomerular podocytes,massangial cells and renal tubular cells.Based on the diversity and importance of p62 protein functions,it may turn to be a candidate of therapeutic target in renal diseases in future.