TRIM8在神经系统中的作用研究进展

Progress on the role of TRIM8 protein in nervous system

三结构域蛋白(TRIM蛋白)家族属于E3泛素连接酶,具有广泛的分子功能,在神经系统中参与神经细胞的发生、发育、增殖和分化等。TRIM8是TRIM家族的一员,通过泛素化途径参与许多病理生理过程,如炎症、肿瘤、细胞增殖等。在神经系统疾病中TRIM8参与癫痫、胶质瘤、卒中等的病理过程。该文综述了TRIM8在神经系统疾病中的作用及其作用机制,以期为治疗神经系统疾病提供新思路。

TRIM family proteins are considered to be E3 ubiquitin ligase,which involve in multiple biological processes.They participate in the genesis,development,proliferation and differentiation in the nervous system.TRIM8 is a member of TRIM family.TRIM8 plays divergent roles in many biological processes such as inflammation,tumor,cell proliferation.TRIM8 is involved in the pathological process of epilepsy,glioma,and stroke.This arttde reviews the role and mechanism of TRIM8 in nervous system diseases in order to provide new treatment ideas for the nervous system diseases.