骨碎补治疗外伤性骨折作用机制的研究进展

Research progress on mechanism of Drynariae Rhizoma in treatment of traumatic fracture

外伤性骨折是临床骨科常见病和多发病,积极有效促进骨折愈合对改善患者预后具有重要临床价值。骨碎补可促进骨髓间充质干细胞分化、促进成骨细胞增殖、抑制破骨细胞活性、促进软骨细胞生长、抑制氧化应激反应、调节相关分子信号通络。探讨了骨碎补促进骨折愈合、治疗外伤性骨折的作用机制,为骨碎补临床上提供参考。

Traumatic fracture is a common and frequently-occurring disease in clinical orthopaedics.Active and effective promotion of fracture healing has important clinical value in improving the prognosis of patients.Drynariae Rhizoma can promote the differentiation of bone marrow mesenchymal stem cells,promote the proliferation of osteoblasts,inhibit the activity of osteoclasts,promote the growth of chondrocytes,inhibit the oxidative stress response,and regulate related molecular signaling.This paper summarizes the mechanism of Drynariae Rhizoma in treatment of traumatic fractures,and provides reference for Drynariae Rhizoma to promote fracture healing in clinic.