青蒿琥酯抗结直肠癌作用机制的研究进展

Research progress on mechanism of artesunate against colorectal cancer

结直肠癌是临床常见消化系统恶性肿瘤,具有较高的发病率和死亡率。青蒿琥酯是从菊科植物黄花蒿中提取的青蒿素衍生物,除抗疟作用外,可通过诱导细胞凋亡,抑制癌细胞增殖、侵袭和转移,抑制新血管形成,促进活性氧生成,抗炎,抗氧化应激反应发挥抗结直肠癌作用。探讨青蒿琥酯抗结直肠癌的作用机制,为青蒿琥酯的临床价值开发提供依据。

Colorectal cancer is a common clinical malignant tumor of digestive system with high morbidity and mortality.Artesunate is an artemisinin derivative extracted from the Compositae plant Artemisia annua Linn.In addition to its antimalarial effect,artesunate can induce apoptosis,inhibit cancer cell proliferation,invasion,and metastasis,inhibit the formation of new blood vessels,and promote reactive oxygen species generation,anti-inflammatory,and anti-oxidative stress to exert anti-colorectal cancer effects.This article discusses the mechanism of artesunate against colorectal cancer,hoping to provide evidence for the clinical value of artesunate.