摘要
人参皂苷是一种三萜皂苷类化合物,研究发现其对乳腺癌具有治疗潜力。基于人参皂苷的分子分型,综述了人参皂苷抗乳腺癌的主要药理作用,其作用机制为诱导乳腺癌细胞的凋亡、调节乳腺癌细胞的周期和增殖、促进乳腺癌细胞自噬、对乳腺癌中上皮细胞-间充质转变(epithelial-mesenchymal transition,EMT)的调节,对其进一步临床应用具有一定的指导意义。
Ginsenosides are triterpenoid saponins,and studies have reported ginsenosides have the potential of treatment of breast cancer. Based on molecular typing of ginsenosides,the main pharmacological effects of ginsenosides against breast cancer were reviewed. The mechanisms of action are inducing apoptosis of breast cancer cells,regulating the cycle and proliferation of breast cancer cells,promoting autophagy in breast cancer cells,and regulating of the epithelial-mesenchymal transition(EMT) in breast cancer,which has certain guiding significance for their further clinical application.
作者
徐子晨
范子祥
王文倩
孟帅
崔海燕
朱明宇
王婧斯
张鲁
XU Zi-chen;FAN Zi-xiang;WANG Wen-qian;MENG Shuai;CUI Hai-yan;ZHU Ming-yu;WANGJing-si;ZHANG Lu(Tianjin Cancer Hospital Airport Hospital,Tianjin 300308,China;National Clinical Research Center for Cancer,Tianjin Clinical Research Center for Cancer,Key Laboratory of Breast Cancer Prevention and Treatment,Ministry of Education,Tianjin Medical University Cancer Institute&Hospital,Tianjin 300060,China;Increasepharm(Tianjin)Institute Co.,Ltd.,Tianjin 300385,China;Tianjin Institute of Pharmaceutical Research,Tianjin 300462,China)
出处
《中草药》
CAS
CSCD
北大核心
2022年第20期6601-6610,共10页
Chinese Traditional and Herbal Drugs
基金
天津市教委科研计划项目(2019KJ187)
天津医科大学肿瘤医院种子基金项目(1810)
天津市“131”创新型人才培养工程第二层次(2018)
西青区专业技术人才“金字塔”培养工程(2019)。
