摘要
转位蛋白(translocator protein,TSPO)是近年来受到关注的一种恶性胶质瘤的生物标记物。TSPO是一种线粒体外膜蛋白,正常情况下在中枢神经系统中TSPO的表达较低,在胶质瘤中经常过表达,其表达水平与WHO分级、胶质瘤细胞增殖、患者预后不良呈正相关。因此TSPO PET显像可应用于胶质瘤的非侵入性检查。TSPO PET显像是在胶质瘤的肿瘤微环境研究中,是重要的一环。在临床的应用中,对于胶质瘤的早期诊断及胶质瘤类型的预判也具有前景。
Translocator protein(TSPO)is a biomarker of malignant glioma that has attracted attention in recent years.TSPO is a mitochondrial outer membrane protein.The expression of TSPO is low in the normal central nervous system,and it is often overexpressed in glioma.The expression level of TSPO is significantly correlated with WHO classification,glioma cell proliferation and poor prognosis.Therefore,TSPO PET imaging can be used in the noninvasive examination of glioma.TSPO PET imaging plays an important role in the study of glioma tumor microenvironment.In the clinical application,the early diagnosis of glioma and the prediction of the type of glioma are also promising.
作者
张慧玮
李克
侯为华
周艳丽
陈星荣
ZHANG Huiwei;LI Ke;HOU Weihua;ZHOU Yanli;CHEN Xingrong(Department of Nuclear Medicine,Jinshan Hospital,Fudan University,Shanghai 201508,China;PET Center,Huashan Hospital,Fudan University;Department of Radiology,Huashan Hospital,Fudan University)
出处
《中国医学计算机成像杂志》
CSCD
北大核心
2022年第5期563-565,共3页
Chinese Computed Medical Imaging
基金
国家自然科学基金(81901367)
复旦大学附属金山医院启动基金(1102)
核医学与分子影像四川省重点实验室开放课题(HYX21002)。
关键词
转位蛋白
正电子断层显像
胶质瘤
Translocator protein
Positron Emission Tomography
Glioma