转位蛋白PET显像在胶质瘤中的临床研究进展

Advances in Clinical Studies of Translocator Protein PET Imaging in Gliomas

转位蛋白(translocator protein,TSPO)是近年来受到关注的一种恶性胶质瘤的生物标记物。TSPO是一种线粒体外膜蛋白,正常情况下在中枢神经系统中TSPO的表达较低,在胶质瘤中经常过表达,其表达水平与WHO分级、胶质瘤细胞增殖、患者预后不良呈正相关。因此TSPO PET显像可应用于胶质瘤的非侵入性检查。TSPO PET显像是在胶质瘤的肿瘤微环境研究中,是重要的一环。在临床的应用中,对于胶质瘤的早期诊断及胶质瘤类型的预判也具有前景。

Translocator protein(TSPO)is a biomarker of malignant glioma that has attracted attention in recent years.TSPO is a mitochondrial outer membrane protein.The expression of TSPO is low in the normal central nervous system,and it is often overexpressed in glioma.The expression level of TSPO is significantly correlated with WHO classification,glioma cell proliferation and poor prognosis.Therefore,TSPO PET imaging can be used in the noninvasive examination of glioma.TSPO PET imaging plays an important role in the study of glioma tumor microenvironment.In the clinical application,the early diagnosis of glioma and the prediction of the type of glioma are also promising.