摘要
树突状细胞(dendritic cell,DC)是一类强大的抗原提呈细胞,也是适应性免疫应答的关键步骤,对于诱导T、B细胞介导的细胞免疫和体液免疫是必需的。由于其特殊的免疫学功能,在DC疫苗的研究中备受关注。目前已有一种基于DC的疫苗Sipuleucel-T获批上市,还有多项DC疫苗正在临床试验阶段。本文对DC的生物学特征和功能、DC疫苗的类型以及DC疫苗面临的挑战和前景作一综述。
Objective Dendritic cell(DC)is a powerful class of antigen-presenting cells and a key step in adaptive immune response,which is necessary for the induction of T-and B-cell-mediated cellular and humoral immunities.Because of specific immunological function,DC have been paid more attention in the research on DC vaccines. A DCbased vaccine,Sipuleucel-T,has been approved for marketing,and several other DC vaccines are in clinical trials. This paper reviews the biological characteristics and functions of DC as well as the types,challenges and prospect of DC vaccines.
作者
李兴航(综述)
李琦涵(审校)
LI Xing-hang;LI Qi-han(Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases,Institute of Medical Biology,Chinese Academy of Medical Science&Peking Union Medical College,Kunming 650118,Yunnan Province,China)
出处
《中国生物制品学杂志》
CAS
CSCD
北大核心
2022年第10期1242-1248,共7页
Chinese Journal of Biologicals
基金
云南省科技计划-生物医药专项(202102AA310043)
国家重点研发计划(2020YFC0860600)。
关键词
树突状细胞
疫苗
肿瘤
预防
治疗
Dendritic cells
Vaccine
Tumor
Prevention
Treatment
