let-7a及其靶基因在肝细胞癌中作用机制的研究进展

Progress in research on mechanism of let-7a and its target genes in hepatocellular carcinoma

肝细胞癌(hepatocellular carcinoma,HCC)是全球范围内最具侵袭性的恶性肿瘤之一,具有较高的复发率和死亡率。大多数恶性肿瘤中微小RNA(microRNA,miRNA)呈异常表达,可影响肿瘤的发生、发展、转移和复发。miRNA可通过靶向不同靶基因,参与不同信号通路,从而在疾病的发生发展、生物发育、器官形成、病毒防御、表观调控及代谢等生命活动起到调控作用。let-7a是let-7 miRNA家族成员之一,参与细胞的增殖、凋亡等生物学过程,且在多种癌症中发挥肿瘤抑制因子的作用。本文就let-7a及其靶基因在HCC中作用机制的研究进展作一综述。

Hepatocellular carcinoma(HCC)is one of the most aggressive malignant tumors in the world,with high recurrence rate and mortality. In most malignant tumors,microRNAs(miRNAs)have been found to be abnormally expressed,thus affect the occurrence,development,metastasis and recurrence of tumors,which play a regulatory role in life activities such as the occurrence and development of diseases,biological development,organ formation,virus defense,epigenetic regulation and metabolism by targeting various target genes and participating in various signaling pathways. Let-7 is a miRNA. As a member of let-7 family,let-7a is involved in biological processes such as cell proliferation and apoptosis and plays the role of tumor suppressor in a variety of cancers. Therefore,this paper reviews the mechanism of let-7A and its target genes in HCC.