鱼腥草抗氧化应激机制研究进展

Research Progress on the Mechanism of Anti-oxidative Stress in Houttuynia cordata Thunb

活性氧的产生和抗氧化防御系统之间的失衡启动氧化应激相关信号通路,引发机体炎症性疾病,恢复氧化应激平衡是治疗自由基类疾病治疗的重要举措。鱼腥草作为一种药食同源的植物,被广泛应用于多种疾病,如糖尿病、高血压、心血管疾病、肺炎等治疗,鱼腥草提取液及其所包含的多种生物活性成分包括多糖、黄酮、挥发油等,在体内、外模型上都表现出很强的抗氧化活性;研究报道鱼腥草可针对多个信号通路调节氧化应激反应,进而发挥其在疾病治疗方面的作用。在概述鱼腥草提取液及其生物活性成分抗氧化应激反应的基础上,主要综述近年鱼腥草在氧化应激相关信号通路方面的调控作用,为鱼腥草抗氧化应激相关疾病的研究提供视角。

The imbalance between the production of reactive oxygen species and the antioxidant defense system initiates oxidative stress-related signaling pathways,triggering inflammatory diseases in the body,and restoring the balance of oxidative stress is an important measure for the treatment of free radical diseases.Houttuynia cordata,as a plant with the same medicine and food,is widely used in the treatment of various diseases including diabetes,hypertension,cardiovascular disease,pneumonia,etc.The extract of Houttuynia cordata and its various biologically active ingredients,including polysaccharides,flavonoids,volatile oils,etc.,have shown strong antioxidant activity in vivo and in vitro models.In addition,Houttuynia cordata can reduce oxidative stress response to multiple signaling pathways,and then play its role in disease treatment.Based on an overview of the antioxidant stress response of Houttuynia cordata extract and its biologically active ingredients,the regulatory efects of Houttuynia cordata in recent years in oxidative stress-related signal pathways have been mainly reviewed,which provides perspective on disease research related to the antioxidant stress of Houttuynia cordata.