血浆SP1、sFlt1、Ghrelin与早发型重度子痫前期患者胎儿生长受限的关系分析

Relationship between plasma SP1, sFlt1 and Ghrelin and fetal growth restriction in patients with early-onsetsevere preeclampsia

目的分析血浆妊娠特异性β_(1)糖蛋白(SP1)、可溶性FMS样酪氨酸激酶-1(sFlt1)、生长激素释放肽(Ghrelin)与早发型重度子痫前期患者胎儿生长受限(FGR)的关系.方法回顾性分析我院2018年9月至2020年9月收治的73例早发型重度子痫前期患者的临床资料,根据胎儿生长受限情况将其分为FGR组(n=41)和非FGR组(n=32),对比两组孕妇血浆SP1、sFlt1、Ghrelin水平,采用Pearson相关性分析血浆SP1、sFlt1、Ghrelin水平与胎儿体质量的相关性,采用ROC曲线分析血浆SP1、sFlt1、Ghrelin对早发型重度子痫前期患者胎儿生长受限的预测效能.结果FGR组血浆SP1水平明显低于非FGR组(P<0.05),FGR组血浆sFlt1、Ghrelin水平明显高于非FGR组(P<0.05).胎儿体质量与血浆sFlt1、Ghrelin呈负相关(P<0.05),与血浆SP1呈正相关(P<0.05).SP1、sFlt1、Ghrelin曲线AUC明显大于参考线(P<0.05),其cut-off值为95.88mg/L、33.83μg/L、16.54μg/L.结论血浆SP1、sFlt1、Ghrelin与早发型重度子痫前期患者FGR关系紧密,血浆SP1、sFlt1、Ghrelin水平还能有效预测FGR的发生,具有较高临床检测价值.

Objective To analyze the relationship of plasma pregnancy-specific β1 glycoprotein(SP1),soluble FMS-like tyrosine kinase-1(sFlt1) and growth hormone releasing peptide(Ghrelin)with fetal growth restriction(FGR) in patients with early-onset severe preeclampsia.Methods The clinical data of 73 patients with early-onset severe preeclampsia who were treated in the hospital between September 2018 and September 2020 were retrospectively analyzed, and the patients were divided into FGR group(n=41) and non-FGR group(n=32)according to fetal growth restriction.The levels of plasma SP1,sFlt1 and Ghrelin were compared between the two groups of pregnant women.Pearson correlation analysis was used to analyze the correlation between plasma SP1,sFlt1 and Ghrelin levels and fetal body mass, and ROC curve was adopted to analyze the predictive efficiency of plasma SP1,sFlt1,and Ghrelin on fetal growth restriction in patients with early-onset severe preeclampsia.Results The plasma SP1 level in FGR group was significantly lower than that in non-FGR group(P<0.05) while the plasma sFlt1 and Ghrelin levels were significantly higher than those in non-FGR group(P<0.05).Fetal body mass was negatively correlated with plasma sFlt1 and Ghrelin(P<0.05),and was positively correlated with plasma SP1(P<0.05).The AUCs of SP1,sFlt1 and Ghrelin curves were significantly larger than the reference lines(P<0.05),and the cut-off values were 95.88 mg/L,33.83 μg/L and 16.54 μg/L.Conclusion Plasma SP1,sFlt1 and Ghrelin are closely related to FGR in patients with early-onset severe preeclampsia.Plasma SP1,sFlt1 and Ghrelin levels can also effectively predict the occurrence of FGR and have high clinical detection value.