原发性玻璃体视网膜淋巴瘤诊断面临的机遇和挑战

Chances and challenges of diagnosing primary vitreoretinal lymphoma

原发性玻璃体视网膜淋巴瘤(PVRL)患者生存期短,死亡率高,尽早确诊具有生存优势。然而,由于PVRL临床表现多样,影像学检查缺乏特异性,作为“金标准”的病理学诊断率低,廹使临床医师寻找更多的诊断方法。细胞因子、免疫组织化学、分子生物学及分子遗传学分析等检测手段虽然有助于提高诊断率,但仍需要眼科医师提高对PVRL临床表现及影像特征的认知,在合理使用现有检测方法的基础上积极探索更加可靠科学的检查手段。

The patients with primary vitreoretinal lymphoma(PVRL)had a short survival and high mortality,thus urge early diagnosis of this disease was helpful to have the survival superiority.However,due to the variety of clinical manifestations of PVRL,the lack of specificity of imaging examination and the low diagnostic rate of pathology as the gold standard,clinicians were inspirited to find more easy-to-use and valuable methods to assist diagnosis.The detection methods such as cytokines,immunohistochemistry,molecular biology and molecular genetics were of benefit to improve the diagnosis rate,but it was important for ophthalmologists to improve the comprehension of the manifestations and imaging characteristics of PVRL and actively explore more reliable and scientific methods based on the available detection methods.