瑞马唑仑复合舒芬太尼在无痛超声胃镜检查中的应用

Application of Remimazolam Combined with Sufentanil in Painless Ultrasound Gastroscopy

目的探讨瑞马唑仑复合舒芬太尼在无痛超声胃镜检查中的应用。方法126例拟接受超声胃镜检查的患者采用随机数字表法随机分为3组:舒芬太尼组(S组):0.01μg·kg^(-1)舒芬太尼;瑞马唑仑组(R组):0.01μg·kg^(-1)舒芬太尼+瑞马唑仑;丙泊酚组(P组):0.01μg·kg^(-1)舒芬太尼+丙泊酚,每组42例。记录3组患者检查时间;记录3组患者麻醉前(T_(0))、胃镜置入后1 min(T_(1))、胃镜置入后3 min(T_(2))、苏醒后5min(T_(3))的平均动脉压(MAP)、心率(HR)、脉搏血氧饱和度(SpO_(2));观察3组患者术中呛咳、呼吸抑制、低血压、需要处理的低血压、心动过缓、误吸、注射痛、术后恶心呕吐发生情况;评估医生和患者的满意度。结果R组和P组的检查时间少于S组,差异有统计学意义(P<0.05)。T_(1)、T_(2)时,S组MAP、Sp O_(2)高于R组,且R组MAP高于P组,差异有统计学意义(P<0.05);T_(2)时,R组和P组HR低于S组,差异有统计学意义(P<0.05)。R组、P组呛咳发生率差异无统计学意义,且均低于S组,差异有统计学意义(P<0.05);P组低血压、需要治疗的低血压、呼吸抑制、注射痛的发生率明显高于R组和S组,差异有统计学意义(P<0.05);3组患者术后恶心呕吐差异无统计学意义(P>0.05)。R组和P组的医生和患者的满意度差异无统计学意义,且均高于S组,差异统计学意义(P<0.05)。结论瑞马唑仑复合舒芬太尼应用于无痛超声胃镜检查麻醉效果好,不良反应发生率低,在临床中具有推广价值。

OBJECTIVE To investigate the effect of remimazolam combined with sufentanil in painless ultrasound gastroscopy.METHODS Totally 126 patients scheduled for ultrasound gastroscopy were randomly divided into the following groups:S,sufentanil (0.01μg·kg^(-1));R,sufentanil (0.01μg·kg^(-1)) followed by remimazolam;P,sufentanil (0.01μg·kg^(-1)) followed by propofol,using a random number table method,with 42 cases in each group.The operation time of patients in three groups were recorded.The mean arterial pressure (MAP),heart rate(HR) and pulse oxygen saturation (SpO_(2)) were recorded before anesthesia (T_(0)),1 min after endoscopy (T_(1)),3min after endoscopy (T_(2)),and 5 min after awakening (T_(3)) in 3 groups.The incidence of intraoperative cough,respiratory depression,hypotension,hypotension requiring treatment,bradycardia,post operative nausea and vomitting,injection pain were evaluated in three groups.The satisfaction of the physician and patient was scored.RESULTS The operation time of group R and group P was shorter than that of group S (PGroup R>Group P (PGroup R=Group P (P0.05).The satisfaction of physician and patients in Group R and Group P was similiar,but was higher than that in Group S (P<0.05).CONCLUSION Remimazolam combined with sufentanil shows good anesthesia effect and low incidences of adverse reactions in painless ultrasonic gastroscopy,which may be worth promoting in clinical practice.