摘要
衰老是指随着年龄的增长,机体生理功能发生逐渐衰退的过程。细胞衰老在多种年龄相关疾病中起重要作用。在不同生物体中发现的衰老特征包括基因组不稳定性、端粒磨损、表观遗传改变、蛋白质稳态丧失、营养感应失调、线粒体功能障碍、细胞衰老、干细胞衰竭和细胞间通讯改变。本文重点综述了近年来衰老相关研究的新进展,包括与衰老相关的分子机制、衰老研究领域的新技术,以及抗衰老研究的新成果,并对衰老机制和抗衰老研究的未来发展进行了展望。
Aging is a complex biological process accompanied by a time-dependent functional decline that affects most living organisms.Cellular senescence plays an important role in a variety of age-related diseases.The hallmarks of aging identified in different organisms,include genomic instability,telomere attrition,epigenetic alterations,loss of proteostasis,dysregulated nutrient sensing,mitochondrial dysfunction,cellular senescence,stem cell exhaustion,and altered intercellular communication.This paper reviews the new research progress on aging in recent 3 years,which includes senescence related signaling pathways and mechanisms,new technologies in the field of aging research,and new achievements in anti-aging research,and finally prospects the future development of aging mechanism and anti-aging research.
作者
张婧
毛根祥
Jing Zhang;Genxiang Mao(Zhejiang Provincial Key Lab of Geriatrics,Geriatrics Institute of Zhejiang Province,Hangzhou 310013,China)
出处
《中华老年病研究电子杂志》
2022年第2期1-8,共8页
Chinese Journal of Geriatrics Research(Electronic Edition)
基金
国家自然科学基金项目(81771520、81701393)
浙江省自然科学基金项目(LY21H250001)
浙江省卫生健康科技计划项目(2021KY014)。
关键词
衰老
抗衰老
机制
衰老相关分泌表型
单细胞测序
Aging
Anti-aging
Mechanism
Senescence-associated secretory phenotype
Single cell RNA sequencing
