老年人肠道菌群与肌少症

Intestinal flora and sarcopenia in the elderly

随着人体衰老,肠道菌群的结构和多样性发生不同程度的失衡,某些细菌的成分、代谢产物及其介导的信号通路可能参与了年龄相关的肌少症的发生、发展。本文重点从老年人肠道菌群的特点,肠道菌群对骨骼肌质量、成分和功能的影响,以及潜在的作用机制进行综述,旨在为基于肠道菌群早期干预改善肌肉质量和功能提供理论参考。

Imbalance of the structure and diversity of intestinal flora are common in elderly.The components,metabolites of some bacteria and their mediated signaling pathways may be involved in the occurrence and development of age-related sarcopenia.This paper reviews the characteristics of intestinal microbiota in the elderly,its effects on skeletal muscle mass,composition and function,and the research progress on the potential mechanisms,aiming to provide theoretical reference for early intervention based on intestinal microbiota to improve muscle mass and function.