胃低级别上皮内瘤变内镜下射频消融术后复发患者处置的临床研究

Clinical study on the management of patients with recurrent gastric low-grade intraepithelial neoplasia after endoscopic radiofrequency ablation

目的本文通过回顾性对比分析,探索胃低级别上皮内瘤变射频消融术后复发患者的临床处置策略。方法回顾性选择2014年10月至2022年9月于我中心完成胃低级别上皮内瘤变射频消融治疗术后复发的53例患者,依据其是否接受追加治疗分为随访组与治疗组,对比两组的相关指标。结果随访组与治疗组在性别、年龄、病程、病变部位、随访时长方面没有明显差异(P>0.05),但治疗组病变消除率明显优于随访组(91.3%vs 43.3%,P<0.001),而治疗组三种术式间的疗效差异尚不显著(P=0.640)。结论对于胃低级别上皮内瘤变射频消融术后复发的患者,建议追加内镜下毁损或切除治疗。

Objective To explore the clinical management strategy of patients with recurrent gastric low-grade intraepithelial neoplasia after radiofrequency ablation.Methods 53 patients with recurrent gastric low-grade intraepithelial neoplasia who completed radiofrequency ablation in our center from October 2014 to September 2022 were retrospectively selected and divided into follow-up group and treatment group according to whether they received additional treatment.The relevant indicators of the two groups were compared and analyzed.Results There were no significant differences in gender,age,course of disease,site of lesion and duration of follow-up between the two groups(P>0.05),but the elimination rate of lesion in the treatment group was significantly better than that in the follow-up group(91.3%vs 43.3%,P<0.001).However,there was no significant difference between the three surgical methods in the treatment group(P=0.640).Conclusion Additional endoscopic ablation or resection is recommended for patients with recurrent gastric low-grade intraepithelial neoplasia after radiofrequency ablation.