布地奈德福莫特罗联合噻托溴铵吸入剂治疗慢性阻塞性肺疾病的疗效

Efficacy of Budesonide Formoterol Combined with Tiotropium Bromide Inhalation in the Treatment of Chronic Obstructive Pulmonary Disease

目的研究布地奈德福莫特罗联合噻托溴铵吸入剂治疗慢性阻塞性肺疾病的疗效。方法选取2020年1月-2021年10月佳木斯市中心医院收治的40例慢性阻塞性肺疾病患者,采用随机数字表法分为对照组与观察组,各20例。对照组给予布地奈德福莫特罗吸入治疗,观察组给予布地奈德福莫特罗联合噻托溴铵吸入剂治疗,比较两组临床疗效、肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、第1秒用力呼气量占肺活量百分比(FEV1%)]、血气指标[血氧饱和度(SaO_(2))、动脉血二氧化碳分压(PaCO_(2))、pH值]、炎性指标[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]。结果观察组治疗总有效率为100.00%,高于对照组的85.00%(P<0.05)。观察组治疗后FVC、FEV1、FEV1%、SaO_(2)、pH高于对照组,PaCO_(2)、CRP、IL-6、TNF-α低于对照组(P<0.05)。结论布地奈德福莫特罗联合噻托溴铵吸入剂治疗慢性阻塞性肺疾病的疗效确切,可有效改善患者的肺功能及血气指标,抑制炎性反应,有利于病情转归。

Objective To study the efficacy of budesonide formoterol combined with tiotropium bromide inhalation in the treatment of chronic obstructive pulmonary disease.Methods Forty patients with chronic obstructive pulmonary disease admitted to Jiamusi Central Hospital from January 2020 to October 2021 were selected and divided into a control group and an observation group according to the random number table method,with 20 cases in each group.The control group was treated with budesonide formoterol inhalation,and the observation group was treated with budesonide formoterol combined with tiotropium bromide inhalation.The clinical efficacy,pulmonary function indexes[forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),forced expiratory volume in the first second as a percentage of vital capacity(FEV1%)],blood gas indexes[blood oxygen saturation(SaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),pH value],inflammatory indexes[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]were compared between the two groups.Results The total effective rate of treatment in the observation group was 100.00%,which was higher than 85.00%in the control group(P<0.05).After treatment,FVC,FEV1,FEV1%,SaO_(2) and pH in the observation group were higher than those in the control group,while PaCO_(2),CRP,IL-6 and TNF-αwere lower than those in the control group(P<0.05).Conclusion Budesonide formoterol combined with tiotropium bromide inhalation is effective in the treatment of chronic obstructive pulmonary disease,which can effectively improve the lung function and blood gas index of patients,inhibit the inflammatory response,and is conducive to the prognosis of the disease.