注射用甲泼尼龙琥珀酸钠联合特布他林雾化吸入治疗慢性支气管炎急性发作期的效果及安全性分析

Effect and Safety Analysis of Methylprednisolone Sodium Succinate for Injection Combined with Terbutaline Aerosol Inhalation in the Treatment of Acute Exacerbation of Chronic Bronchitis

目的分析注射用甲泼尼龙琥珀酸钠联合特布他林雾化吸入治疗慢性支气管炎急性发作(AECB)的效果及安全性。方法选取2019年1月-2021年6月上饶市广信区血防站急诊科收治的56例AECB患者,使用随机数字表法分为对照组(28例)与观察组(28例)。对照组采用注射用甲泼尼龙琥珀酸钠治疗,观察组采用注射用甲泼尼龙琥珀酸钠联合特布他林雾化吸入治疗,比较两组临床疗效、肺功能[呼气流量峰值(PEF)、最大通气量(MVV)、第一秒用力呼气量(FEV1)]、血气指标[血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))]、实验室指标[白细胞(WBC)、中性粒细胞计数(NEUT)、C反应蛋白(CRP)]、不良反应。结果观察组治疗总有效率为96.43%,高于对照组的82.14%(P<0.05);两组治疗后PEF、MVV、FEV1指标均升高,且观察组高于对照组(P<0.05);两组治疗后PaO_(2)升高,PaCO_(2)降低,且观察组PaO_(2)高于对照组,PaCO_(2)低于对照组(P<0.05);两组治疗后WBC、NEUT、CRP水平均降低,且观察组低于对照组(P<0.05);观察组不良反应发生率为7.14%,低于对照组的28.57%(P<0.05)。结论注射用甲泼尼龙琥珀酸钠联合特布他林雾化吸入治疗AECB的疗效确切,可有效改善患者的肺功能及血气状态,恢复其血常规指标,减少药物不良反应。

Objective To analyze the efficacy and safety of methylprednisolone sodium succinate for injection combined with terbutaline inhalation in the treatment of acute exacerbation of chronic bronchitis(AECB).Methods A total of 56 patients with AECB admitted to the Emergency Department of the Guangxin District Blood Prevention Station in Shangrao City from January 2019 to June 2021 were selected and divided into a control group(28 cases)and an observation group(28 cases)by random number table method.The control group was treated with methylprednisolone sodium succinate for injection,while the observation group was treated with methylprednisolone sodium succinate for injection combined with terbutaline aerosol inhalation.The clinical efficacy,pulmonary function[peak expiratory flow(PEF),maximum ventilation(MVV),forced expiratory volume in one second(FEV1)],blood gas indexes[partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2))],laboratory indexes[white blood cell(WBC),neutrophil count(NEUT),C-reactive protein(CRP)]and adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group was 96.43%,which was higher than 82.14%in the control group(P<0.05).After treatment,PEF,MVV and FEV1 indexes in the two groups increased,and those in the observation group were higher than the control group(P<0.05).After treatment,PaO_(2) increased and PaCO_(2) decreased in the two groups,and PaO_(2) in the observation group was higher than that in the control group,and PaCO_(2) was lower than that in the control group(P<0.05).The levels of WBC,NEUT and CRP in the two groups decreased after treatment,and the levels in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 7.14%,which was lower than 28.57%in the control group(P<0.05).Conclusion Methylprednisolone sodium succinate for injection combined with terbutaline aerosol inhalation is effective in the treatment of AECB,which can significantly improve the lung function and blood gas status of patients,restore their blood routine indicators,and reduce adverse drug reactions.