孕中期血清学筛查在产前诊断和妊娠结局预测中的应用价值分析

Analysis on application value of serological screening in the second trimester of pregnancy in prenatal diagnosis and pregnancy outcome prediction

目的探讨分析在孕中期产前诊断和妊娠结局预测中,采用血清学筛查的应用价值。方法选取2020年1-12月于福建省泉州市泉港区妇幼保健院进行常规产前检查的732例孕中期孕妇为研究对象,均行血清学筛查,以筛查结果作为筛查组,以妊娠结局作为实际组,对比两组的检出准确率情况。结果在孕中期血清学筛查中,筛查组中正常妊娠的患者688例,占比93.98%,不良妊娠的患者44例,占比6.02%,实际妊娠结局中,实际组正常妊娠的患者685例,占比93.57%,不良妊娠的患者47例,占比6.43%,两组检出率差异无统计学意义(P>0.05)。在具体不良妊娠结果中,筛查组检出早产儿15例,地中海贫血10例,唐氏综合征5例,神经管畸形5例,先天性心脏病5例,其他4例;实际组结果早产儿15例,地中海贫血12例,唐氏综合征6例,神经管畸形5例,先天性心脏病5例,其他4例,总体来看在早产儿检出、先天性心脏病检出等多种不良妊娠结果检查中均由较高的检出率,两组检出率差异无统计学意义(P>0.05)。结论在孕中期产前诊断和妊娠结局预测中,采用血清学筛查能够有效地对患者存在的不良妊娠问题进行检查,从而为临床治疗与诊断、预测产妇妊娠结局提供明确的参考标准与指导意义,具有较高的临床应用价值。

Objective To explore the application value of serological screening in the second trimester prenatal diagnosis and pregnancy outcome prediction.Methods A total of 732 cases of pregnant women in the second trimester of pregnancy who received routine prenatal examination in the Spring Harbor Maternal and Child Health Care from January to December 2020 were selected as the research objects.All pregnant women in the second trimester of pregnancy underwent serological screening.The screening results were taken as the screening group,and the pregnancy outcomes were taken as the actual group.The detection accuracy of the two groups was compared.Results In the second trimester of pregnancy serological screening,688 cases of patients with normal pregnancy in the screening group,accounting for 93.98%,44 cases of patients with adverse pregnancy,accounting for 6.02%.In the actual pregnancy outcome,685 cases of patients with normal pregnancy in the actual group,accounting for 93.57%,47 cases of patients with adverse pregnancy,accounting for 6.43%,the difference was not statistically significant(P>0.05).In the specific adverse pregnancy results,15 cases of preterm infants,10 cases of thalassemia,5 cases of Down's syndrome,5 cases of neural tube malformation,5 cases of congenital heart disease and 4 other cases were detected in the screening group;In the actual group,there were 15 cases of premature infants,12 cases of thalassemia,6 cases of Down's syndrome,5 cases of neural tube malformation,5 cases of congenital heart disease and 4 other cases.Generally speaking,the detection rate of premature infants,congenital heart disease and other adverse pregnancy results was higher,and there was no statistically significant difference between the two groups(P>0.05).Conclusion In the second trimester prenatal diagnosis and pregnancy outcome prediction,serological screening can effectively check the adverse pregnancy problems of patients,so as to provide a clear reference standard and guiding significance for clinical treatment and diagnosis and prediction of maternal pregnancy outcome,which has high clinical application value.