基于数据挖掘的中药专利复方治疗原发性肝癌用药规律

Medication rule of TCM patent compound prescriptions for the treatment of primary liver cancer based on data mining

目的通过数据挖掘方法分析国家专利数据库中药复方治疗原发性肝癌的用药规律。方法检索纳入国家专利检索平台中治疗原发性肝癌的中药复方,通过中医传承辅助平台等软件对所纳入的复方进行频次统计分析、关联分析和聚类分析。结果共纳入治疗原发性肝癌专利复方350个,涉及中药425味;使用频次排名前10的高频中药依次为白花蛇舌草、黄芪、半枝莲、白术、甘草、人参、柴胡、莪术、丹参、当归;前3位药物功效类别依次为补虚药、清热解毒药、活血化瘀药;药性以寒、温、平为主,药味以苦、甘、辛居多,归经以肝、脾、肺经为要;发现关联规则12条,关联性最强的药对为"白花蛇舌草-半枝莲",高频药物可聚为8组。结论中药专利复方治疗原发性肝癌以益气健脾为主,辅以清热解毒、活血化瘀之品,与原发性肝癌"扶正祛邪,攻补兼施"的基本治则相一致。本研究挖掘探讨了中药专利复方治疗原发性肝癌的基本用药规律,以期为临床实践提供指导。

Objective To analyze the medication rule of TCM compound prescription in the treatment of Primary Liver Cancer(PLC)in the National Patent Database by the method of data mining.Methods By searching for the compound prescriptions of TCM which were included in the National Patent Retrieval Platform for the treatment of PLC,and analyzing the frequency,association and cluster of those included compound prescriptions through the inheritance and assistance platform of TCM.Results A total of 350 patent prescriptions for the treatment of PLC were included,involving 425 Chinese medicines;the top 10 frequently appeared herbal medicines were Hedyotis diffusa,Radix Astragali,Scutellaria barbata,Atractylodes macrocephala,Glycyrrhiza uralensis,Ginseng,Radix Bupleuri,Rhizoma Curcumae,Salvia miltiorrhiza and Angelica sinensis;according to the function of those medicines,the top three frequently appeared herbal medicines were those with deficiency-tonifying heat-clearing and detoxifying,promoting blood circulation and removing blood stasis functions;the property of the medicine were mainly cold,warm and mild;the taste of the medicine were mainly bitter,sweet and acrid;the meridians of the medicines mainly belong to liver,spleen and lung.It was found that there were 12 association rules,and the medicine pair that were closely correlated was"Hedyotis diffusa-Scutellaria barbata",and the most frequently appeared medicines could be grouped into 8 groups.Conclusions The TCM patent compound prescriptions mainly play the role of replenishing qi and invigorating the spleen,supplemented by the products of clearing heat and detoxification,activating blood circulation and removing blood stasis,which is consistent with the basic treatment principle of PLC"invigorate the upright and dispel the evil,attack the evil and tonify the body".This study explores the basic medication rules of TCM patent compound prescription in the treatment of PLC,in order to provide guidance for clinical practice.