益生菌活性代谢产物的研究及应用进展

Research and Application Progress of the Active Metabolites of Probiotics

益生菌因对机体具有多种益生功效而逐渐成为研究热点。益生菌的多种益生特性与其代谢产生的活性产物密切相关。益生菌的活性代谢产物主要有胞外多糖、细菌素、维生素、有机酸和短链脂肪酸等,它们在抗炎症、抗氧化、调节免疫、预防或治疗代谢性疾病等方面发挥积极作用,很多已被用于医疗、食品防腐、畜牧养殖等多个行业中。尽管益生菌活性代谢产物有较好的益生功能和应用潜力,但在提高产量、降低生产纯化成本、探明作用机制等方面仍需进行深入探索。本文主要对益生菌活性代谢产物的种类、功能及其应用等方面进行综述,为其在食品、医疗、保健、畜牧等领域的研究应用提供更多参考。

Probiotics is an intriguing research focus due to its multiple beneficial effects on host,which is closely associated with its bioactive metabolites,including extracellular polysaccharides,bacteriocins,vitamins,organic acids and short-chain fatty acids.They are widely used in medical treatment,food antiseptic,animal husbandry and other industrial areas for their broad beneficial effects,such as anti-inflammation,anti-oxidation,immune regulation and preventive and therapeutic properties against metabolic diseases.Even though the functionalities and application potential of probiotics are extensively studied,further efforts are needed to focus on the increase of their productivity,reducing the cost of production and purification and exploring the cellular and molecular mechanisms.Here we review the category,functions and applications of probiotic metabolites,and would provide more insights for their utilizations in food,medicine,health care and animal husbandry.