海洋生物活性肽的制备、分离纯化及构效关系研究进展

Research Progress on Preparation,Separation,Purification and Structure-Function Relationship of Marine Bioactive Peptides

海洋生物活性肽是一类结构多样且具有多种功能和活性的肽类,其制备、分离纯化和生物活性受到了广泛关注。已有不少相关研究证明海洋生物活性肽是一类很具开发潜力的新型药物来源。然而,整合海洋生物活性肽制备技术和生物应用的研究还较缺乏,为此本文综述了近年来海洋生物活性肽制备、分离纯化的方法,并阐述了其原理、优缺点、适用对象和未来发展趋势,介绍了海洋生物活性肽的抗氧化、抗糖尿病、降血压、抗菌、抗癌等功能活性,并深入探讨了其构效关系和未来发展方向,以便为开发新型海洋药物提供有力理论依据。

Marine bioactive peptides are a kind of peptides with various structures,functions and activities.The production and preparation,separation and purification as well as biological activities have attracted much attention.It's already proved by many researches that marine bioactive peptides are a new drug source with a lot of potential.However,research on the integration of marine bioactive peptide preparation technology and biological application is still lacking.In this paper,the methods of production and preparation,separation and purification of marine bioactive peptides in recent years are reviewed.The principles,advantages and disadvantages,applicable objects and future development trend are expounded while the functional activities of marine bioactive peptides such as anti-oxidation,anti-diabetes,lowering blood pressure,anti-bacterial and anti-cancer are introduced.The structure-activity relationship and the future development direction of marine bioactive peptides are explored in depth so as to provide a strong theoretical basis for developing the new marine drugs.