中枢介导的腹痛综合征与抑郁症共病机制研究进展

Progress in understanding of comorbid mechanism of centrally mediated abdominal pain syndrome and depression

疼痛通常与个体行为和情绪有关,慢性腹痛症状的出现预示着抑郁症更严重和更不利的结果,与健康相关的生活质量更差,故缓解疼痛症状是治疗中枢介导的腹痛综合征(CAPS)与抑郁症的一个共同目标。CAPS共病抑郁症的相关机制尚不清楚,但越来越多的研究结果提示两者可能存在一些共同的发病机制。本文对近年来CAPS与抑郁症的关联研究和两者发病的共同机制进行综述。

Pain is usually related to individual behaviors and emotions.The occurrence of chronic abdominal pain symptoms predicts more severe and adverse outcomes of depression and poorer healthrelated quality of life.Therefore,relief of pain symptoms is a common goal in the treatment of centrally mediated abdominal pain syndrome(CAPS)and depression.The comorbid mechanism of CAPS and depression is still not clear,but more and more research suggests that CAPS and depression may have some common pathogenesis.This article reviews the research on the relationship between CAPS and depression in recent years and the common pathogenesis of the two.