TNF-α在绝经后骨质疏松症中的研究进展

Progress in research of TNF-αin postmenopausal osteoporosis

肿瘤坏死因子-α(TNF-α)作为一种有效的促炎细胞因子,可刺激免疫细胞活化,促进炎症因子分泌,打破钙磷平衡,介导破骨细胞和成骨细胞的分化,通过多种途径调节骨代谢,参与绝经后骨质疏松症的发生发展,有望成为治疗绝经后骨质疏松症的药物靶点。本文分析TNF-α在绝经后骨质疏松症中的作用,以期为绝经后骨质疏松症的治疗提供新的方法。

Tumor necrosis factorα(TNFα),as an effective pro-inflammatory cytokine,can stimulate the activation of immune cells,promote the secretion of inflammatory factors,break the balance of calcium and phosphorus metabolism,mediate the differentiation of osteoclasts and osteoblasts,regulate bone metabolism through various ways,and participate in the occurrence and development of postmenopausal osteoporosis,which is expected to be a drug target for the treatment of postmenopausal osteoporosis.This article analyzes the role of TNFαin postmenopausal osteoporosis and provides a new method for the treatment of postmenopausal osteoporosis.