不同手术方法治疗子宫颈上皮内瘤变Ⅱ、Ⅲ级患者的效果及对炎症因子的影响

Effect of Different Surgical Methods on the Treatment of Cervical Intraepithelial NeoplasiaⅡ,Ⅲand Its Influence on Inflammatory Factors

目的:通过研究不同手术方法对子宫颈上皮内瘤变(CIN)Ⅱ、Ⅲ级患者临床疗效及炎症因子的影响,为该疾病的临床治疗提供依据。方法:选取九江市第一人民医院2018年1月-2021年6月收治的CINⅡ、Ⅲ级患者80例,根据随机数字表法将患者分为观察组和对照组,各40例。对照组采用子宫颈冷刀锥切术(CKC),观察组采用子宫颈环形电切除术(LEEP)。观察两组临床疗效、围手术期相关指标、炎症因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-10(IL-10)]水平及术后并发症发生情况。结果:观察组总有效率为97.50%,高于对照组的80.00%(P<0.05)。观察组手术时间、住院时间、切口愈合时间均短于对照组,且术中出血量少于对照组(P<0.05)。术后1个月,观察组CRP、TNF-α、IL-10均低于对照组(P<0.05)。两组术后并发症发生率比较,差异无统计学意义(P>0.05)。结论:对CINⅡ、Ⅲ级患者行LEEP可缩短手术时间、住院时间、切口愈合时间,减少术中出血量,减轻机体炎性反应,临床疗效显著,值得推广使用。

Objective:To study the effects of different surgical methods on clinical efficacy and inflammatory factors in patients with cervical intraepithelial neoplasia(CIN)ⅡandⅢ,and provide a basis for the clinical treatment of this disease.Method:A total of 80 patients with CINⅡandⅢadmitted to Jiujian NO.1 People’s Hospital from January 2018 to June 2021 were selected and divided into an observation group and a control group according to the random number table method,40 cases in each group.The control group was treated with cervix cold knife conization(CKC),and the observation group was treated with cervix loop electrosurgical excision procedure(LEEP).The clinical efficacy,perioperative related indexes,levels of inflammatory factors[C reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin 10(IL-10)]and postoperative complications were observed in the two groups.Result:The total effective rate of the observation group was 97.50%,which was higher than 80.00%of the control group(P<0.05).The operation time,hospital stay and incision healing time in the observation group were shorter than those of the control group,and the intraoperative bleeding amount was less than that of the control group(P<0.05).One month after operation,the levels of CRP,TNF-αand IL-10 in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of postoperative complications between the two groups(P>0.05).Conclusion:LEEP in patients with CINⅡandⅢcan shorten the operation time,hospital stay,incision healing time,reduce intraoperative bleeding amount,and reduce the inflammatory response of the organism,which is clinically effective and worth promoting.