活体肝移植供肝脂肪变性评估研究进展

Research progress of hepatic steatosis evaluation evaluate in living donor liver transplantation

脂肪变性供肝作为边缘性供肝,已成为扩展供肝来源的重要渠道。因此,肝移植术前评估供肝脂肪变性程度尤为重要。临床判断肝脂肪变性发展程度以肝穿刺活检结果作为依据,但给患者带来一定创伤风险。随着影像学和生物学检测技术的不断发展,超声、CT、MRI、磁共振波谱分析和生物标志物等已被用于评估肝移植供肝脂肪变性程度。本文综述上述临床手段在评估脂肪变性供肝质量方面的研究进展,分析其在临床应用中的优缺点,为临床安全、快速和无创评估脂肪变性供肝提供参考。

Donor livers with steatosis as a type of marginal donor livers,has become an important channel to expand the source of donor livers.Therefore,it is important to evaluate the degree of steatosis before liver transplantation.The clinical judgment on the state of hepatic steatosis is based on the results of liver biopsy,but it brings a certain risk of trauma to patients.With the continuous development of imaging and biological detection technologies.The clinical methods including ultrasound,CT,MRI,magnetic resonance spectroscopy and biomarkers have been used to evaluate the degree of hepatic steatosis in liver transplantation.This article reviews the research progress of the above clinical methods in assessing the quality of donor liver with steatosis,and analyzes their advantages and disadvantages in clinical application,and provides a reference for the safe,rapid and non-invasive assessment of donor liver with steatosis.