胃窦血管扩张症的治疗进展

Research progress of gastric antral vascular ectasia

胃窦血管扩张症(GAVE)是一种原因不明的、以胃窦黏膜条形或弥漫性毛细血管扩张为典型特征的血管畸形性疾病,约占非静脉曲张上消化道出血的4%。临床表现主要为缺铁性贫血和反复的消化道出血,胃镜多能确诊。GAVE的治疗方式主要包括药物、消化内镜和外科手术,目前尚无统一规范的治疗策略。近期,沙利度胺、贝伐珠单抗以及内镜下套扎术、射频术被用于GAVE的治疗,初步表现出令人满意的结果。因此,本文通过系统文献回顾,对GAVE的治疗进展作一综述。

Gastric antral vascular ectasia(GAVE)is a vascular malformation of unknown cause,characterized by strip or diffuse telangiectasia of gastric antral mucosa,which is usually diagnosed by gastroscopy.The main clinical manifestations are iron deficiency anemia and recurrent gastrointestinal bleeding.The major treatment of GAVE includes pharmacotherapy,endoscopy and surgery.Currently,no consensus has been reached on the management of GAVE.Recently,thalidomide and bevacizumab,as well as endoscopic ligation and radiofrequency ablation have been increasingly used in the management of GAVE,preliminarily showing promising results.Therefore,in this review,we reviewed the advances in the treatment of GAVE to provide authoritative clinical references for further treatment.