炎症性肠病发病机制及与肠道菌群关系的研究进展

Advances in the pathogenesis and relationship between intestinal flora and inflammatory bowel disease

炎症性肠病(IBD)是一种慢性反复发作的炎症性肠道疾病,其具体病因尚不明确。IBD主要特征是异常免疫反应所致的肠道炎症,遗传易感基因和环境因素(例如饮食、吸烟、抗生素的应用)是其发病的主要诱因。大量研究已经揭示了肠道菌群在维持肠道稳态中的重要作用,肠道菌群失调不仅影响宿主代谢,也会导致存在遗传易感基因的宿主出现肠道免疫失调,从而诱发肠道炎症。本文对炎症性肠病的发病机制及其与肠道菌群之间的关系进行综述。

Inflammatory bowel disease(IBD)is a type of chronic and recurrent inflammatory bowel disease t the exact etiology of which is unknown.IBD is mainly characterized by intestinal inflammation caused by abnormal immune response.Genetic susceptibility genes and environmental factors such as diet,smoking,and antibiotic use are the main causes of its pathogenesis.A large number of studies have revealed the important role of gut microbiota in maintaining intestinal homeostasis.Intestinal microbiota dysbiosis not only affects host metabolism,but also leads to intestinal immune dysregulation in hosts with genetically susceptible genes,thereby inducing intestinal inflammation.This article reviewed the pathogenesis of inflammatory bowel disease and its relationship with the gut microbiota.