肠道菌群与阿尔兹海默症关系研究进展

Progress in Relationship between Gut Microbiota and Alzheimer’s Disease

肠道菌群是一个复杂而动态的生态系统。近年越来越多的研究表明,肠道菌群在机体代谢和免疫功能等方面具有重要作用,可通过“微生物-肠-脑轴”对阿尔兹海默症(AD)等神经系统疾病发挥调节作用。肠道菌群的组成变化可影响AD的病理学进程,成为AD干预治疗的新靶点,但其相互作用的先后顺序及具体作用机制等很多问题尚不清晰。本文对相关研究进展进行了介绍,以期为进一步认识和研究肠道菌群在AD中的作用提供参考。

Gut microbiota is a complex and dynamic ecosystem.In recent years,increasing evidence has proved the paramount role of gut microbiota in shaping our metabolic and immunological functions,which is also an important regulator for nervous system diseases such as Alzheimer’s disease(AD) through the network called “gut-brainmicrobiota”.Alteration in the composition of gut microbiota can potentially contribute to the pathophysiology of AD and become a new target for therapeutic intervention.However,the order and specific mechanism of interaction between gut microbiota and Alzheimer’s disease remains unclear.This review summarizes introduces the related research progress,in order to provide reference for further understanding and studying the role of gut microbiota in AD.