钙调蛋白依赖性激酶Ⅱ/Ⅳ对抑郁性认知功能障碍中突触可塑性的作用研究

Study of the effects of calmodulin-dependent kinase Ⅱ/Ⅳ on synaptic plasticity in depressive cognitive dysfunction

抑郁性认知功能障碍与抑郁症本身密切相关的认知症状,是认知症状中最主要的类型,贯穿整个抑郁症的发病前期、急性期直至缓解期,是抑郁症核心症状之一。在抑郁症急性发作期,患者的抑郁性认知比较常见,可独立于情感症状或躯体症状之外,部分患者的抑郁性认知会随着情感症状的缓解而减轻。抑郁性认知功能康复是抑郁症最终治疗的目标。钙调蛋白依赖性激酶在调节突触可塑性,与改善抑郁性认知障碍息息相关。该文就钙调蛋白依赖性激酶Ⅱ/Ⅳ对抑郁性认知障碍的调节作用与机制研究做一综述。

Depressive cognitive dysfunction is a cognitive symptom closely related to depression itself and is the most important type of cognitive symptoms. It runs through the onset, acute and remission stages of depression, and is one of the core symptoms of depression. During the acute episode of depression, the depressive cognition of patients is relatively common, which can be independent of emotional symptoms or physical symptoms. The depressive cognition of some patients will be reduced with the relief of emotional symptoms. The rehabilitation of depressive cognitive function is the ultimate goal of depression treatment. Calmodulin dependent kinases regulate synaptic plasticity and are closely related to the improvement of depressive cognitive impairment. This paper reviews the regulatory effect and mechanism of calmodulin dependent kinase Ⅱ/Ⅳ on depressive cognitive impairment.