功能性消化不良脑-肠-微生态的研究及中医药治疗进展

Brain-gut-microecology in Functional Dyspepsia and the Treatment with Traditional Chinese Medicine:A Review

功能性消化不良是临床常见病、难治病,现代医学疗效有限。“脑-肠-微生态”是脑-肠轴与肠道菌群之间双向调节的新概念,这一概念与功能性消化不良的发病机制密切相关,现梳理了目前功能性消化不良与“脑-肠-微生态”之间关系的研究进展,同时针对中医药治疗功能性消化不良具有辨证施治、整体调理、不良反应小、可长期使用等特点,结合“药以治病,医以疗心”的治疗思路,最大程度地发挥中医药治疗功能性消化不良的优势,可为基础研究提供参考,为临床中西医结合、病证结合方法提供借鉴。

Functional dyspepsia is a common refractory disease in clinical settings,and modern medicine has limited efficacy.“Brain-gut-microecology”is a new concept of two-way regulation between the“brain-gut axis”and the intestinal flora,which is closely related to the pathological mechanism of functional dyspepsia.This article summarized the research on the relationship between functional dyspepsia and“brain-gut-microecology”.Meanwhile,based on the characteristics of traditional Chinese medicine in the treatment of functional dyspepsia,such as syndrome differentiation,holistic regulation,small side effects,and long-term use,and the treatment principle of“alleviating physical disease with medicine while emphasizing emotional regulation”,the advantages of traditional Chinese medicine can be made full use in the treatment of functional dyspepsia.This review is expected to serve as a reference basic research and clinical treatment with integrated traditional Chinese and western medicine and the combination of disease and syndrome.