黄芪基于经典名方物质基准的质量控制进展

Research Progress on Quality Control Methods of Huangqi(Astragali Radix) Based on Material Benchmark of Classical Prescriptions

黄芪是传统的补中益气类中药,具有补气升阳、固表止汗、利水退肿等功效,广泛应用在经典名方及中药复方制剂中。在解读经典名方物质基准各阶段研究过程质量控制要求的同时,对近年来相关文献中黄芪及黄芪水溶性成分的质量控制方法以及多层次的质量控制模式,如特征图谱、指纹图谱、一测多评、超高效液相色谱-串联质谱法等多成分质量控制新技术进行归纳总结,以期为黄芪在经典名方物质基准中质量控制的应用提供科学参考及依据。

Huangqi(Astragali Radix) is a kind of traditional Chinese medicine, which has the functions of invigorating Qi and promoting Yang, strengthening the surface, stopping perspiration, promoting water and reducing swelling. It is widely used in the classical famous prescriptions and Chinese medicine compound preparations. In this paper, the quality control methods and multi-level quality control models of Huangqi(Astragali Radix) and its water-soluble components in recent years, such as characteristic map, fingerprint map, one test and multi-assessment, liquid chromatography-mass spectrometry and other new multi-component quality control technologies, were summarized while interpreting the requirements of quality control in the research process of each stage of the material standard of the classic prescriptions, in order to provide reference and scientific basis for the application of quality control in material benchmark of Huangqi(Astragali Radix).