帕妥珠单抗及曲妥珠单抗联合化疗就早期乳腺癌辅助治疗临床效果评估

Evaluation of Clinical Effect of Pertuzumab and Trastuzumab Combined with Chemotherapy in Adjuvant Therapy for Early Breast Cancer

目的 探究帕妥珠单抗及曲妥珠单抗联合化疗就早期乳腺癌辅助治疗临床效果评估。方法 选取2018年10月—2021年10月江苏省启东市人民医院接受诊治的92例早期乳腺癌患者为研究对象。依据临床医嘱用药差异均分为两组,各46例。对照组予多西他赛(T)联合环磷酰胺(C)双药化疗;观察组则予以帕妥珠单抗及曲妥珠单抗联合化疗。对比两组治疗效果、不良反应发生以及预后情况。结果 观察组临床总有效率(89.13%)高于对照组(69.57%),差异有统计学意义(χ^(2)=5.373,P=0.020);不良反应发生率(8.70%)低于对照组(30.43%),差异有统计学意义(χ^(2)=6.907,P=0.009);且疾病转移率(6.52%)低于对照组(26.09%),差异有统计学意义(χ^(2)=6.452,P=0.011)。结论 在早期乳腺癌辅助治疗中实施帕妥珠单抗及曲妥珠单抗联合化疗的效果理想,其能有效提高患者治疗效果,降低不良反应发生率,改善其预后。

Objective To evaluate the clinical effect of Pertuzumab and Trastuzumab combined with chemotherapy in adjuvant therapy for early breast cancer.Methods A total of 92 patients with early breast cancer who were diagnosed and treated in People′s Hospital of Qidong City in‐Jiangsu Province from October 2018 to October 2021 were selected.According to the differences of clinical doctor′s orders,they were divided into two groups,46 cases in each group.The control group was treated with docetaxel (T) combined with cyclophosphamide (C) double-drug chemotherapy,while the observation group was treated with pertuzumab and trastuzumab combined with chemotherapy.The treatment effect occurrence of adverse reactions and prognosis of the two groups were evaluated and compared.Results The total clinical effective rate(89.13%) in the observation group was higher than that in the control group (69.57%),and the difference was statistically significant (χ^(2)=5.373,P=0.020).The incidence of adverse reactions (8.70%) was lower than that of the control group (30.43%),and the difference was statisti‐cally significant (χ^(2)=6.907,P=0.009).And the disease metastasis rate (6.52%) was lower than the control group (26.09%),and the difference was statistically significant (χ^(2)=6.452,P=0.011).Conclusion The effect of pertuzumab and trastuzumab combined with chemotherapy in the adjuvant treatment of early breast cancer is ideal,which can effectively improve the treatment effect of patients,reduce the occurrence of ad‐verse reactions,and improve their prognosis.