不同浓度氢吗啡酮对罗哌卡因硬膜外分娩镇痛效应的影响分析

Influence of Different Concentrations of Hydromorphone on Epidural Labor Analgesia of Ropivacaine

目的研究不同浓度氢吗啡酮对罗哌卡因硬膜外分娩镇痛效应的影响效果。方法选择潼南区妇幼保健院在2018年1月—2020年1月期间收治的100例临产妇患者作为研究对象,按照随机数表法对所选对象进行分组,分为A组、B组、C组、D组,每组25例。A组患者单纯通过罗哌卡因镇痛,B组患者通过罗哌卡因和5μg/mL的氢吗啡酮联合镇痛,C组患者通过罗哌卡因和10μg/mL的氢吗啡酮联合镇痛,D组患者通过罗哌卡因和15μg/mL的氢吗啡酮联合镇痛,4组给药剂量、速度均相同。比较4组患者给药前、给药后5 min、15 min、30 min的疼痛评分,镇痛起效时间,Bromage评分。结果给药前和给药后5 min,4组患者的疼痛评分比较,差异无统计学意义(P>0.05);给药后15 min、30 min,B组患者的疼痛评分分别为(2.98±0.16)分、(2.53±0.08)分,低于其他3组患者,差异有统计学意义(F=16.066、28.842,P<0.05);4组患者的镇痛起效时间比较,差异无统计学意义(P>0.05);4组患者的Bromage评分比较,差异无统计学意义(P>0.05)。结论硬膜外分娩镇痛过程中,应用5μg/mL的氢吗啡酮联合罗哌卡因进行镇痛,能够更好地降低患者疼痛程度,镇痛效应影响效果更佳。

Objective To study the effect of hydromorphone at different concentrations on epidural labor analgesia of ropivacaine.Methods A total of 100 pregnant women admitted to Tongnan District Maternal and Child Health Hospital from January 2018 to January 2020 were selected as the research objects.Then the selected subjects were divided into group A,group B,group C,and group D according to the random number table method,with 25 cases in each group.Patients in group A were given ropivacaine for analgesia alone,patients in group B were given combined analgesia with ropivacaine and 5μg/mL hydromorphone,patients in group C were given combined analgesia with ropivacaine and 10μg/mL hydromorphone pain,and patients in group D received combined analgesia with ropivacaine and 15μg/mL hydromorphone,and the four groups were administered at the same dose and speed.The pain score before administration and 5 min,15 min,and 30 min after administration,analgesic onset time and Bromage score before and after administration were compared among the four groups.Results There was no statistically significant difference in pain scores between the four groups before administration and 5 minutes after administration(P>0.05).15 min and 30 min after administration,the pain scores of patients in group B were(2.98±0.16)points and(2.53±0.08)points,which were lower than those of the other three groups,and the difference was statistically significant(F=16.066,28.842,P<0.05).There was no statistically significant difference in the onset time of analgesia among the four groups(P>0.05).There was no statistically significant difference in Bromage score among the four groups(P>0.05).Conclusion In the process of epidural labor analgesia,the application of 5μg/mL hydromorphone combined with ropivacaine for analgesia can better reduce the pain degree of patients,and has a better analgesic effect.