主动循环热灌注化疗用于卵巢癌腹腔积液的效果观察

Effect of active circulation hyperthermic perfusion chemotherapy on ovarian cancer ascites

目的探讨卵巢癌腹腔积液患者采用主动循环热灌注化疗的疗效,为临床提供参考。方法选取2018年10月至2021年2月江苏省苏北人民医院收治的50例卵巢癌伴腹腔积液患者作为研究对象,按随机数字表法分为对照组和观察组,各25例。对照组患者使用常规化疗方式进行治疗,观察组患者采用主动循环热灌注化疗。比较两组患者化疗后肿瘤及腹腔积液疗效、化疗不良反应发生率及1年生存率,并检测两组患者化疗前后血清中肿瘤相关标记物水平,包括血管内皮生长因子(VEGF)、糖类抗原125(CA125)、人附睾蛋白4(HE-4)。结果观察组患者肿瘤疾病控制率明显高于对照组(P<0.05);观察组患者腹腔积液治疗总有效率及疾病控制率明显高于对照组(P<0.05);化疗后两组患者VEGF、CA125、HE-4水平均比化疗前低,且观察组比对照组低(P<0.05);两组患者化疗不良反应发生率比较,差异无统计学意义(P>0.05);观察组患者1年生存率显著高于对照组(P<0.05)。结论卵巢癌伴腹腔积液患者采用主动循环热灌注化疗的疗效较好,可有效降低肿瘤相关标记物水平,短期生存率更高,且未增加不良反应。

Objective To investigate the effect of active circulation hyperthermic perfusion chemotherapy in ovarian cancer patients with abdominal effusion,and to provide clinical reference.Methods 50 patients with ovarian cancer and ascites admitted to Jiangsu Subei People’s Hospital from October 2018 to February 2021 were selected as research objects,and were divided into control group and observation group according to random number table,with 25 patients in each group.The patients in the control group were treated with conventional chemotherapy,while the patients in the observation group were treated with active circulation hot perfusion chemotherapy.The therapeutic effect of tumor and ascites,incidence of adverse reaction and 1-year survival rate were compared between the two groups after chemotherapy,and the levels of serun tumor related markers in ascites,including vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125),and human epididymal protein 4(HE-4),were detected before and after chemotherapy.Results The cancer control rate of observation group was significantly higher than that of control group(P<0.05).The total effective rate and disease control rate of ascites in the observation group were significantly higher than those in the control group(P<0.05).After chemotherapy,the levels of EGF,CA125 and HE-4 in the two groups were lower than those before chemotherapy,and the observation group was lower than the control group(P<0.05).There was no significant difference in the incidence of chemotherapy adverse reactions between the two groups(P>0.05).The 1-year survival rate of the observation group was significantly higher than that of the control group(P<0.05).Conclusion Active cyclic hyperthermic infusion chemotherapy is effective in the treatment of ovarian cancer patients with ascites,which can effectively reduce the level of tumor-related markers,improve the short-term survival rate,and does not increase the adverse reactions.