非小细胞肺癌化疗前后血清糖类抗原125、基质金属蛋白酶-9、可溶性程序性死亡配体1水平变化及其与疗效关系研究

Changes of serum CA125,MMP-9 and sPD-L1 levels before and afteRchemotherapy in non-small cell lung canceRand theiRrelationship with therapeutic effect

目的:分析非小细胞肺癌(NSCLC)患者化疗前后血清糖类抗原(CA)125、基质金属蛋白酶-9(MMP-9)、可溶性程序性死亡配体1(sPD-L1)水平变化及其与疗效的关系。方法:选择接受顺铂+依托泊苷(EP)化疗的NSCLC患者95例为研究对象。采集所有患者化疗前和化疗后2个周期时的外周血,检测血清CA125、MMP-9、sPD-L1水平。于化疗4周后评价疗效。比较化疗前后及不同疗效NSCLC患者血清CA125、MMP-9、sPD-L1水平。采用Logistic回归分析血清CA125、MMP-9、sPD-L1水平与疗效的关系。采用受试者工作特征(ROC)曲线分析血清CA125、MMP-9、sPD-L1水平对化疗疗效的预测价值。结果:化疗后NSCLC患者血清CA125、MMP-9较化疗前显著下降(均P<0.05),PD-L1与治疗前比较差异无统计学意义(P>0.05)。部分缓解(PR)和疾病稳定(SD)的NSCLC患者化疗后血清CA125、MMP-9、PD-L1较化疗前下降,疾病进展(PD)的NSCLC患者血清CA125、MMP-9、PD-L1较化疗前上升(均P<0.05)。化疗前后血清CA125、MMP-9、PD-L1是NSCLC患者化疗疗效的独立影响因素。NSCLC患者化疗后血清CA125、MMP-9、PD-L1均对化疗疗效有较高的预测价值。结论:NSCLC患者化疗后血清CA125、MMP-9、sPD-L1水平与化疗疗效存在密切关联,对化疗疗效有较高的预测价值。

Objective:To analyze the changes of serum carbohydrate antigen(CA)125,matrix metalloproteinase-9(MMP-9)and soluble programmed death ligand-1(sPD-L1)levels before and afteRchemotherapy in non-small cell lung canceR(NSCLC)and theiRrelationship with therapeutic effect.Methods:A total of 95 NSCLC patients who underwent cisplatin combined with etoposide(EP)chemotherapy were selected as the research subjects.The peripheral blood of all patients before chemotherapy and 2 cycles afteRchemotherapy was collected to detect serum CA125,MMP-9 and sPD-L1 levels.The therapeutic effect was evaluated afteR4 weeks of chemotherapy.The serum CA125,MMP-9 and sPD-L1 levels were compared before and afteRchemotherapy and in NSCLC patients with different curative effects.Logistic regression was used to analyze the relationship between serum CA125,MMP-9,sPD-L1 levels and therapeutic effect.ROC curve was used to analyze the predictive value of serum CA125,MMP-9 and sPD-L1 levels on chemotherapy efficacy.Results:AfteRchemotherapy,serum CA125 and MMP-9 in NSCLC patients were significantly decreased compared with those before chemotherapy(all P<0.05),and there was no significant difference in PD-L1 compared with that before treatment(P>0.05).The serum CA125,MMP-9 and PD-L1 of NSCLC patients with partial remission(PR)and stable disease(SD)decreased afteRchemotherapy compared with those before chemotherapy,while the serum CA125,MMP-9 and PD-L1 of NSCLC patients with progressive disease(PD)increased compared with those before chemotherapy(all P<0.05).Serum CA125,MMP-9 and PD-L1 before and afteRchemotherapy were independent influencing factors of chemotherapy efficacy in NSCLC patients.Serum CA125,MMP-9 and PD-L1 in NSCLC patients afteRchemotherapy had high predictive value foRchemotherapy efficacy.Conclusion:The levels of serum CA125,MMP-9 and sPD-L1 are closely related to the therapeutic effect in non-small cell lung canceRpatients afteRchemotherapy,which are of high predictive efficiency foRtherapeutic effect of chemotherapy.