摘要
抗肿瘤疫苗是癌症免疫疗法的一种。由于癌细胞表面高表达多种癌症相关抗原分子,利用这类分子可激活树突状细胞抗原呈递,激活辅助性T细胞和细胞毒性T细胞的免疫响应,从而清除相应的癌细胞。抗肿瘤疫苗在黑色素瘤、白血病等癌症的临床研究中取得了很好的效果。现就基于常见肝癌相关抗原如甲胎蛋白(AFP)、磷脂酰肌醇蛋白聚糖3(GPC3)、多药耐药相关蛋白3(MRP3)、癌症-睾丸抗原(CTA)设计的靶向肝癌的抗肿瘤疫苗的临床研究进行综述。
Anti-tumoRvaccines are a type of canceRimmunotherapy.Due to the high expression of a variety of cancer-related antigen molecules on the surface of canceRcells,the use of such molecules can activate dendritic cell antigen presentation and activate the immune response of helpeRT cells and cytotoxic T cells,thereby eliminating the corresponding canceRcells.Anti-tumoRvaccines have achieved good results in clinical studies of melanoma,leukemia and otheRcancers.This article reviews the clinical studies of anti-tumoRvaccines targeting liveRcanceRbased on common liveRcancer-associated antigens such as alpha-fetoprotein(AFP),phosphatidylinositol proteoglycan 3(GPC3),multidrug resistance-associated protein 3(MRP3)and cancer-testis antigen(CTA).
作者
吴许军
李文阳
张甲戌
WU Xujun;LI Wenyang;ZHANG Jiaxu(Affiliated Hospital of Gansu Medical College,Pingliang 744000,China)
出处
《陕西医学杂志》
CAS
2022年第12期1611-1613,1617,共4页
Shaanxi Medical Journal
基金
甘肃省科技计划项目(21CX6NG298)。
关键词
肝癌
抗肿瘤疫苗
甲胎蛋白
磷脂酰肌醇蛋白聚糖3
多药耐药相关蛋白3
癌症-睾丸抗原
HepatocellulaRcarcinoma
Anti-tumoRvaccine
Alpha-fetoprotein
Phosphatidylinositol proteoglycan 3
Multidrug resistance-associated protein 3
Cancer-testis antigen
