pH/温度双重响应型介孔二氧化硅载药微球的制备及缓释性能研究

Preparation of mesoporous silica drug-loading microspheres with dual response to pH/temperature and study on their slow-release properties

采用溶胶-凝胶法制备介孔二氧化硅微球(mSiO),以羧甲基壳聚糖(CMCS)、N-异丙基丙烯酰胺(NIPAM)和丙烯酰胺(AM)自由基聚合的接枝共聚体对介孔二氧化硅进行功能化改性,制备出具有pH和温度双重响应的介孔二氧化硅纳米药物载体mSiO@CMCS/NIPAM/AM。通过SEM、TM、FT-IR等表征手段分析该药物载体的结构性能。结果表明,以盐酸阿霉素(DOX)为模型药物,当pH为7时,DOX的平衡吸附量为94.99 mg/g,载药率为9.05%,包封率为66.59%。对搭载了DOX的药物载体进行释药实验,在pH为5.7、温度43℃时,DOX的累积释放率达到71%。

Mesoporous silica microspheres(mSiO)are prepared by sol-gel method,and is modified functionally by graft copolymer among carboxymethyl chitosan(CMCS),N-isopropylacrylamide(NIPAM)and acrylamide(AM)to prepare mesoporous silica drug carrier(mSiO@CMCS/NIPAM/AM)with dual response to pH and temperature.The structure and properties of the drug carrier are analyzed by SEM,TM and FT-IR.It is verified that the equilibrium adsorption capacity of doxorubicin hydrochloride is 94.99 mg·g^(-1),the drug loading rate reaches 9.05%and the entrapment efficiency reaches 66.59%when doxorubicin hydrochloride is used as the model drug and pH is 7.The cumulative release rate of doxorubicin hydrochloride reaches 71%at pH=5.7 and 43℃.